| Names | |
|---|---|
| Preferred IUPAC name | 2-[4-ethenylphenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol |
| Other names | 4-HFA-ST 2-(4-vinylphenyl)-1,1,1,3,3,3-hexafluoro-2-propanol |
| Pronunciation | /tuː fɔːr eˈθɛ.nɪl.faɪˈniːl wʌn wʌn wʌn θriː θriː θriː hɛks.əˈflʊə.rəˌprəʊ.pæn tuː ɒl/ |
| Identifiers | |
| CAS Number | 3952-78-1 |
| Beilstein Reference | 3918732 |
| ChEBI | CHEBI:145459 |
| ChEMBL | CHEMBL1316372 |
| ChemSpider | 21542415 |
| DrugBank | DB14030 |
| ECHA InfoCard | ECHA InfoCard: 100.136.621 |
| EC Number | 695-997-2 |
| Gmelin Reference | 78938 |
| KEGG | C18704 |
| MeSH | D000073650 |
| PubChem CID | 22222972 |
| RTECS number | YZ0150000 |
| UNII | ECE2Z567MG |
| UN number | 3272 |
| Properties | |
| Chemical formula | C11H6F6O |
| Molar mass | 284.17 g/mol |
| Appearance | Colorless liquid |
| Odor | Characteristic. |
| Density | 1.43 g/mL |
| Solubility in water | insoluble |
| log P | 2.93 |
| Vapor pressure | 0.13 mmHg (25 °C) |
| Acidity (pKa) | 12.5 |
| Basicity (pKb) | 8.35 |
| Magnetic susceptibility (χ) | -7.13 × 10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.419 |
| Viscosity | 662 cP (25 °C) |
| Dipole moment | 2.7712 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 211.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -933.25 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -3821.7 kJ·mol⁻¹ |
| Pharmacology | |
| ATC code | Not assigned |
| Hazards | |
| GHS labelling | GHS02, GHS07 |
| Pictograms | GHS02,GHS07 |
| Signal word | Warning |
| Hazard statements | H302, H319, H315 |
| Precautionary statements | P210, P280, P305+P351+P338, P337+P313 |
| NFPA 704 (fire diamond) | 1-3-0-☢ |
| Flash point | > 90 °C |
| Autoignition temperature | 400 °C |
| Lethal dose or concentration | LD50 oral rat: > 2000 mg/kg |
| LD50 (median dose) | >2000 mg/kg (Rat, oral) |
| NIOSH | DJ5750000 |
| PEL (Permissible) | Not established |
| REL (Recommended) | No REL established |
| Related compounds | |
| Related compounds | Hexafluoroisopropanol (HFIP) Styrene 4-Vinylphenol 2,2,2-Trifluoroethanol 2-(4-vinylphenyl)ethanol 3,3,3-Trifluoropropanol 4-Fluorostyrene 2-(4-ethenylphenyl)ethanol |
| Property | Description & Technical Commentary |
|---|---|
| Product Name & IUPAC Name |
2-(4-ethenylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol IUPAC: 2-[4-ethenylphenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol In production records and batch release, the systematic IUPAC name remains the primary identifier to minimize ambiguity. Consistency in naming supports traceability from synthesis to end-use application. |
| Chemical Formula |
C11H8F6O The formula reflects the specific fluorination pattern. Source material integrity and batch-to-batch fidelity are both closely monitored due to the reactivity of fluoroalcohols and their potential for impurity profiles associated with incomplete fluorination. |
| Synonyms & Trade Names |
Synonyms may include 4-HFA-ST, 4-ethenylphenyl hexafluoroisopropanol, vinylstyrylhexafluoroisopropanol. Trade names used by manufacturers are internally systematized for quality assurance tracking and sales specification harmonization. Synonym selection aligns with end-market recognition versus internal compliance documentation. |
| HS Code & Customs Classification |
Typical assignments follow national import/export rules for organofluorine compounds; in most jurisdictions, the HS Code aligns to 2903.39 (Other fluorinated derivatives of acyclic hydrocarbons). Classification reviews periodical updates as per product development and regional customs authority practices. The product’s downstream application—mainly in specialty polymers and advanced resin modifiers—may affect documentary requirements for final users or re-export scenarios. Customs classification is supported by Certificate of Analysis and, when needed, Letters of Declaration per customer request. |
Production integrates strict source material vetting. Hexafluoropropanol intermediates often require rigorous purification to counteract trace byproduct formation from base-catalyzed side reactions. Ethylene functionality (from the 4-ethenyl group) necessitates precise process control over polymerization susceptibility, both in monomer handling and in downstream usage.
Grade selection depends on customer process—whether as a co-monomer in custom polymer synthesis or as a specialty surface treatment intermediate. Specifications are never one-size-fits-all; release purity, moisture content, and residual monomer are agreed upon per documented end-use. Batch consistencies are maintained through analytical (often GC-MS/NMR) validation with tailored impurity thresholds set based on application—especially where medical, electronic, or optoelectronic grade is demanded.
Customs and logistics support must match real-world documentation requirements, not just theoretical classifications. Many customers request pre-clearance review, particularly in high-specification markets such as Japan, Korea, EU customs unions, and US FDA-regulated imports.
Production of 4-HFA-ST typically yields a colorless to faintly tinted liquid. Any evident discoloration points to trace impurities or thermal degradation during distillation. Characteristic odor is generally mild and specific to the fluorinated alcohol structure, intensifying if residual starting material is present or polymerization occurs.
Form, melting point, boiling point, flash point, and density vary slightly across grades and lot history. Precise data are tracked per batch; final values depend on both purification yield and the grade. Minor fluctuations may result from variation in fluorine incorporation or oligomeric byproducts, particularly if reaction control or distillation is inconsistent.
Structure offers strong thermal and chemical stability in absence of excessive heat, acids, or strong bases. Reactivity rises near elevated temperatures or in the presence of radical initiators, which encourages vinyl group participation. Contact with alkali metals or strong oxidizers may induce hazardous byproducts, primarily due to vinyl and perfluoroalcohol moieties.
Soluble in select polar organic solvents, including ethers and some ketones. Miscibility with water is limited, governed by both fluorination and hydrophobic aromatic content. Accurate solubility data requires grade-level validation, especially when trace impurities affect dissolution kinetics or induce microphase separation at high concentrations.
For solution preparation, solvent selection requires compatibility with downstream processes and stability toward the functional groups present.
| Parameter | Industrial Grade | High-Purity Grade |
|---|---|---|
| Purity (% by GC or HPLC) | Grade-dependent, values set by end-user/process need | Higher minimum, aligned with semiconductor or specialty polymer criteria |
| Moisture Content | Production dependent, lower water cut for reactive use | Tighter restriction for applications sensitive to hydrolysis |
| Color (APHA) | In-process monitoring; discoloration tracked as marker for thermal impurity | Stringent maximum for photonic and diagnostics |
| Residual Solvent | Limited in accordance with downstream safety | Specified on lot-release for precision applications |
| Impurity Profile | Typical values depend on process route; byproducts from incomplete fluorination, over-reduction, or oligomerization addressed by purification | Profile resolved at low ppm or ppb per customer spec |
Analytical methods include GC, HPLC, NMR, and Karl Fischer titration, selected based on impurity type and batch criticality. Each production campaign determines precise tests as part of lot-specific batch records and in-process decisions.
Quality release standards are internal and vary by end-user certification (e.g., electronics, pharma, monomer feedstocks).
Selection centers on vinyl-substituted benzene and hexafluoropropanone derivatives certified for low volatile and metallic contamination. Supplier qualification involves contaminant profiling, with alternate sourcing as contingency for regulatory compliance or availability disruptions.
Typical synthesis couples a Friedel-Crafts or catalytic alkylation to introduce vinyl substitution, followed by fluorination and alcohol group incorporation via controlled hydrolysis or reduction. Route adjustments focus on impurity minimization, specifically oligomeric and defluorinated byproducts that compromise reactivity or thermal stability.
Process surveillance includes temperature ramp rates, residence times, and staged distillation under reduced pressure. Removal of HF, unreacted monomer, and process-side products forms a purification bottleneck, dictating cycle times and yield. Consistency demands online chromatographic checks and periodic verification of physical constants.
Each batch follows an internal release protocol. Decision points include color, GC trace, residual solvent, and FTIR verification of functional group incorporation. Impurity trends recalibrate the process upstream, with focus on maintaining reactive group availability for polymerization or crosslinking applications.
The vinyl group enables addition polymerization under free-radical or anionic initiation; reaction conditions leverage inert atmosphere, moderate exotherm management, and regulated initiator addition. Hydroxyl presence allows for acylation, etherification, and further functionalization.
Catalyst and temperature settings respond to downstream requirements. Efforts center on minimizing side-chain scission and preventing oligomeric impurity build-up. Solvent and temperature depend on intended derivative—higher-purity batches may employ anhydrous and low-metal environments.
Major downstream outputs include specialty fluoropolymers, photoresist intermediates, and coupling agents. The balance between reactivity and thermal stability guides selection for further modification or end-use.
Maintain bulk containers under dry, inert gas such as nitrogen. Temperature is best kept low to moderate, with light exclusion in higher purity grades to avoid UV-induced degradation. Drum and glass container compatibility has proven out under both transport and long-term stability trials. Humidity intrusion triggers hydrolysis and discoloration, impacting both performance and shelf appearance.
Signs of degradation include increased color, detectable acidic odor, or phase separation, most observable in lots stored above recommended temperatures or with repeated exposure to air. Shelf life, as acknowledged from ongoing real-time monitoring, is grade-specific and supported by retained sample analytics and accelerated age testing.
Labeling is based on recognized international frameworks, with focus on skin/eye irritation potential and toxicity by inhalation, ingestion, or dermal exposure. Individual GHS codes depend on the country of sale and product concentration.
Key statements highlight risks of respiratory irritation and skin sensitization for operators handling concentrated solutions or during open transfers. Risk communication targets accidental contact scenarios, especially with unpolymerized material.
Official occupational limits vary regionally. Plant procedures use the most conservative threshold from available regulatory and toxicological studies. Operators wear chemical-resistant gloves, goggles, and work in ventilated spaces or closed handling systems. Emergency protocols address accidental spills, considering rapid evaporation and potential for local environmental persistence.
Production output of 4-HFA-ST hinges heavily on access to upstream fluorinated intermediates and substituted styrene routes. Actual output per unit time is directly linked to plant loading, campaign schedule, and reliability of critical feedstock suppliers. Lead batches often reflect seasonal raw material shifts and utility grid fluctuations, particularly in Asia and US Gulf Coast regions. Production ramp-up for high-purity, polymer-grade material extends cycle time and intensifies in-process control compared to technical grade. Delivery for specialty applications may be contingent on qualification runs for each plant and complex logistics due to regulatory restrictions on fluorinated materials in certain jurisdictions.
Standard lead time is defined by batch campaign duration, supplier qualification cycle, and export documentation clearance. Quantities below 50 kg often combine with ongoing scheduled production, while custom grades or special packaging formats may require extended scheduling. For many regions, minimum practical shipment aligns with drum- or crate-based logistics, subject to stability and regulatory transport certification.
Industrial shipment makes use of fluoropolymer-lined drums or intermediate bulk containers, tailored to storage stability, purity retention, and compliance with hazardous goods codes (regional certifications apply for US, EU, Japan). Custom packaging—such as ampoules for analytical grade—entails added QC release steps and traceability documentation. Variation in container specification often tracks directly with customer-specific purity and analytical documentation requirements.
Export control clearance and documentation dictate the feasibility of air or sea shipment, especially for high-fluorine content materials. Payment structure standardizes to advance, irrevocable L/C or milestone-based wire transfer on inspection. Shipping method—ground, air, sea—depends on regulatory permissions, with preference for routes optimizing lead time, handling risk, and customs compliance.
Cost for 4-HFA-ST derives primarily from hexafluoropropanol and phenylvinyl intermediates. Pricing behavior tracks international market swings in fluorine, hydrofluoric acid derivatives, and specialty aromatic precursors. Environmental regulations on HF handling and emissions treatment embed significant cost volatility. Securement of fluorinated reagents—especially from compliant upstream producers—remains a key cost driver, magnified by plant maintenance outages or shifts in global trade flow.
Product price moves notably with grade: high-purity, electronics, or polymerization-specific grades command premiums due to additional purification, impurity control, and analytical lot release. Packaging format (bulk vs. specialty container) and compliance documentation (for GMP or REACH registration) affect final cost structure. Analytical certification and traceability documentation required by advanced markets (e.g., semiconductor, pharmaceutical) translate to higher inspection, documentation, and storage costs. The underlying rationale traces to increased plant time, higher rejection rate, and more intensive QC requirements for these segments.
Production is regionally concentrated, dominated by East Asia (China, Japan, South Korea), with expanded but constrained capacity in North America and Western Europe due to specialty plant requirements and strict emissions regulations. Demand is largely anchored by advanced polymer, electronics, and specialty coating producers. Western demand has seen moderate growth, counterbalanced by Asian capacity expansions and shifting supply routes.
The US and EU markets exhibit high-grade requirements, significant documentation, and tighter scrutiny on C6 fluorochemical use under evolving PFAS rules. Japan maintains advanced manufacturing and steady regional demand for specialty monomers. India’s consumption remains limited by technology adoption and market access, but project-based demand can spike volatility. China serves as both a key supplier and a large domestic consumer, subject to fluctuations tied to domestic policy, plant permitting cycles, and periodic raw material shortages or price caps.
Current trajectory suggests persistent upward pressure on high-purity and specialty-grade pricing through 2026. Key drivers involve environmental policy tightening, cost of compliance with PFAS management, and ongoing fluctuations in fluorinated upstream feedstock. Regional volatility (notably China/EU) will continue to provoke periodic supply-demand mismatches, with premiums for just-in-time and certified product. Commodity-grade pricing will depend on the availability of off-grade or co-product streams and access to recycled HF under new regulatory frameworks.
Analysis draws from internal production campaign records, multi-year purchasing logs, regional chemicals market bulletins, and regulatory updates from international agencies. Price trends supplemented by cross-border sales ledger review, regional capacity surveys, and compliance audit feedback.
Industrial producers have responded to tightening PFAS disposal and reporting rules by investing in advanced abatement plants and shifting to greener synthetic routes. Supply interruptions have emerged from unplanned shutdowns for emissions upgrades or upstream material requalification, most notably in East Asian and EU capacity nodes.
New rules affecting C6 fluorinated chemical handling have come into force across major OECD markets, impacting labeling, transportation certification, and permissible exposure levels. For material shipped into the EU and US, REACH and TSCA documentation require periodic updates, stricter reporting, and compliance with both import reporting and on-site audit.
Manufacturers have expanded backward integration to secure key raw materials, implemented advanced analytical batch tracking, and now employ real-time emissions monitoring to meet evolving regulatory obligations. Contingency stockpiling and diversification of logistics partners reduce risk during regional transport interventions or border control delays.
In-house synthesis of 2-(4-ethenylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol supports a range of industrial needs where vinyl functionality and the presence of hexafluoroisopropanol groups are required. Selection of grade reflects intended downstream performance in target sectors. Key fields include:
| Application Sector | Primary Grade(s) | Key Parameters |
|---|---|---|
| Specialty Polymer Synthesis | Technical Grade, Polymerization Grade | Vinyl content, inhibitor level, moisture, particle size (if supplied solidified), residual monomer content |
| Photoresist/Electronics | Electronics Grade, Low-Metal Grade | Trace metal content, residual solvent, spectrophotometric purity, total organofluorine impurities |
| Surface Modification/Chemical Coating | Industrial Grade | Color, vinyl content, compatibility profile, downstream formulation stability |
| Pharma & High-Purity Fine Chemicals | Pharma Grade, High-Purity Grade | Total organic impurities, residual solvent (ICH Q3C relevance), chiral purity (if application-relevant) |
Grade selection connects directly to the tolerances for specific impurities, water content, and trace metals—factors controlled during isolation and purification based on the foreseen application.
Each downstream sector prescribes its own quality requirements. Technical and polymerization grades allow broader impurity profiles but restrict metal content only where catalyst poisoning is a risk. Electronics and pharmaceutical uses demand stepwise chemical handling processes, routine palladium- and platinum-testing, and stringent color control. Impurity sources range from unconverted starting material to handling-induced water uptake. The degree of drying, filtration, and post-synthesis workup varies with grade, as end-application tolerance for residuals determines processing depth.
Production planning starts from the target application. Requirements for electronics-grade intermediates or polymer feedstocks narrow down the quality route. Identify the end-use before specifying lot size and technical details for consultation with our product development and QC teams.
Check the regulatory standards that impact both procurement and downstream handling. For electronics and pharma clients, we track regional and application-specific mandates, such as allowable metals or process residuals flagged under REACH, RoHS, or ICH. Market destination and client-side QA should confirm requirements before grade selection.
Purity, water, and trace impurity thresholds depend on batch consistency, intended downstream reaction, and environmental or human exposure scenario. Technical grade suits polymer synthesis, while API or electronics intermediates require control of trace metals, colored bodies, and process-specific residual solvents. Our plant can tailor post-synthesis purification—distillation, sublimation, or recrystallization—according to the application’s impurity risk map.
Larger scale polymer customers often favor technical or industrial grades for non-critical applications. Custom or fine chemical projects with low volume but high purity specifications drive different packing, QA checks, and, often, premium pricing due to additional process controls.
Validation in the target process remains the true test of any grade delivered. Sampling allows for empirical fit-to-specification, both in the customer’s pilot process and against final performance or regulatory benchmarks. Feedback cycles then refine the grade or trigger adjustments in production controls.
Production of 4-HFA-ST adheres to a structured quality management framework. Our facilities rely on a documented system that covers traceability of all raw materials, multi-level process audits, and routine internal reviews. Whether the customer’s application targets electronics-grade, pharmaceutical intermediates, or specialty polymers, audits and certifications are aligned to sector-specific requirements. While global standards such as ISO certifications are maintained at the site-level, individual customers with more demanding regulatory expectations are accommodated through additional auditing and reporting upon request. The effectiveness of these measures is periodically validated with both in-house and independent external checks.
Certification profiles for 4-HFA-ST are dependent on both grade and application target. For downstream use in regulated segments, such as advanced electronic materials or life sciences, additional lot-attached declarations, including heavy metal screening or elemental impurity reports, are issued upon customer request. Each production lot can be cross-referenced to batch release standards that may emphasize purity profile, catalyst residues, or residual monomers. The release criteria are always set according to internal technical benchmarks coupled with customer-supplied requirements, with certificate of analysis (CoA) content reflecting either standard or customized parameters. Changes in regulatory or market expectations lead to rapid updates in our technical file and release formats.
Customers receive a full batch traceability record for each consignment of 4-HFA-ST. Standard documentation includes CoA, process flow maps, and, when requested, extended impurity profiles or compliance declarations versus major international chemical control frameworks. Documentation routinely addresses aspects such as critical raw material origins, synthesis route, in-process control points, and control strategy for key impurity classes. Extended reports, often requested by specialty users, cover stability, reactivity, and safe handling data, which are tailored to the customer’s downstream formulation or handling needs. All technical documentation reflects live process conditions and actual analytical findings, never estimated or template-based numbers.
Production output and supply rhythm for 4-HFA-ST are managed through regular capacity planning and real-time inventory tracking. Fixed-supply and make-to-order options are supported, typically explained in terms of the production campaign length, plant turn-around scheduling, and forward raw material commitments. For customers with large annual volumes or fluctuating demand, supply contracts may detail call-off rhythms, buffer stocks, and adjustment procedures during unforeseen market pulses. Cooperation plans explicitly map out responsibilities around forecasts, production slotting, and logistical protocols.
Base capacity is maintained through continuous investment in plant modernization, dual-source raw material supply lines, and modular batch reactors. For 4-HFA-ST, critical process bottlenecks are mapped and regularly stress-tested under real commissioning conditions. Batch consistency receives top attention — every lot is benchmarked to both internal and key customer reference lots to ensure deviation root causes can be isolated and corrected. Customers with high purity or high reactivity grade requirements are engaged in periodic technical exchange on advanced control strategies and supply risk mitigation plans. Supply stabilization is not generic: it pivots on the production route and grade profile.
Sample requests for 4-HFA-ST pass through a structured pre-qualification. Typically, the intended process use, purity dependencies, and formulation sensitivity are reviewed. Production of sample lots frequently mirrors commercial production equipment and batch sizes to maintain scaling validity. Analytical documentation and pre-shipment risk assessment are tailored to the requested application, with special focus on analytical parameters beyond standard certificates for customers active in sensitive downstream areas. Customers receive status updates as samples are in preparation, in quality review, and dispatched.
Business arrangements with partners span fixed-term, volume-based contracts, project-specific one-off deliveries, and rolling forecast-backed flexible call-offs. In each approach, pricing and delivery logistics are tailored to the supply-demand volatility and forward planning horizon. Where customers require adaptive arrangements due to ramping production schedules or sudden changes in specification, our cooperation mode includes technical feedback loops and split delivery options. Extended technical support, such as customization of analytical reports or re-validation for application-specific lots, is built into the cooperation framework. The level of flexibility directly follows from both the grade required and the sophistication of the customer’s formulation or process system.
4-HFA-ST has attracted focused attention due to its electronic activity, anchoring potential in specialty polymers, and compatibility in surface modification chemistries. Industrial R&D groups prioritize control over vinylic reactivity for advanced resin synthesis, especially where fluorinated aromatic core structures improve substrate adhesion, minimize dielectric constant, or resist chemical attack. R&D labs closely monitor impurity carryover, especially fluorinated byproducts affecting polymerization. Most current programs explore copolymerization, photoresist formulation, and OLED intermediate applications, where grade tuning is driven by end-use specification and downstream regulatory screening.
Demand continues to scale from microelectronics and photolithography, where 4-HFA-ST reinforces hybrid resins or serves as a key monomer in advanced dielectric films. Interest from the medical device sector links to its non-leaching surface modification uses. Application development remains sensitive to trace impurity profiles, as these influence optical clarity, film adhesion, and crosslinking stability. Grade-specific requirements include both electronic and pharmaceutical contact-safety levels; these impact purification strategy at scale.
Production consistently faces challenges incorporating fluorinated groups without excessive byproduct persistence. The process route must address fluorination stage selectivity, with key checkpoints at each distillation and phase separation to prevent endpoint drift. Some breakthroughs in reactor design and in-situ fluorine management have helped reduce hazardous intermediate exposure and downstream purification load. For electronics-grade, moisture and ionic trace levels demand batchwise tight control, and this dictates raw material pretreatment and air exclusion practices. Cross-functional teams coordinate between process control and analytical labs to investigate any trace byproduct impact on electronic application performance.
Processor demand for 4-HFA-ST continues to climb in precise electronic and polymer fields. Market signals indicate robust growth from semiconductor material makers and specialty coating formulators. Adopters consistently request volume flexibility and application-dedicated batch histories. Regional demand patterns reflect differences in regulatory acceptance, affecting local technical file requirements and influencing raw material sourcing logistics. Demand for pharmaceutical or medical-adjacent purity grades is growing but requires separate production campaigns and changeover protocols to ensure compliance with trace residue limits.
Anticipated process evolution centers on green byproduct containment and yield maximization. Facility upgrades focus on reactor material upgrades and recovery-loop integration to cut waste and energy usage. Analytical teams invest in inline spectroscopy and real-time impurity drift alerts. Technical alliances with downstream partners drive molecular refinement, aiming for tighter monomer reactivity under milder conditions. Expansion in continuous-flow pilot rigs creates faster transfer from lab to production and minimizes manual handling of hazardous intermediates.
Ongoing review of solvent choices and process waste streams forms the basis of plant-wide sustainability upgrades. Selection of fluorinated raw materials increasingly factors in supplier chain transparency and lifecycle compliance. Engineering efforts focus on solvent recapture and closed-system handling. Core process improvements target energy savings per output kilogram—particularly for grades destined for green electronics and medical applications. Manufacturing schedules for high-purity lots integrate more frequent equipment clearance and in-line contaminant monitoring.
Application engineers remain available for direct end-user collaboration, especially at the pilot trial stage. Support teams review raw material compatibility, downstream process fit, and batch trace documentation. Each technical inquiry is logged and returned with a process-contextual response, referencing production grade, impurity specifications, and potential process bottlenecks. Tailored advice depends on regional regulatory backdrop and customer output profiles.
Field support includes guidance on blending parameters, storage protocols, and contamination risk minimization tailored to the application grade. Technical teams can coordinate with processor R&D labs to interpret monomer reactivity drift, trace instability signals, or process interruption signatures traced to 4-HFA-ST batch variations. On-site visits may follow if persistent formulation concerns surface, and detailed analytical support can be arranged under strict confidentiality.
Each product release aligns with the current internal quality control regime and may be accompanied by a customizable Certificate of Analysis tailored to the customer’s analytical priorities. Trace batch documentation and storage advice are provided upon shipment. A formal feedback mechanism links end-user observations directly to production management, so recurring concerns are escalated to raw material sourcing or process engineering for proactive closure. Replacement or batch requalification protocols activate based on the recorded nature and impact of reported deviation.
At our synthesis facility, every batch of 2-(4-ethenylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol—commonly known as 4-HFA-ST—originates from tightly controlled starting materials and proprietary processes. By operating on-site from raw material purification to reactor optimization and workup, we maintain traceability across all process stages. Instrumentation follows current standards for analytical verification, so buyers receive material with consistent purity and well-defined specifications every shipment.
4-HFA-ST plays a recognized role in specialty polymer synthesis, advanced coating formulations, and electronics. End users depend on it for preparing fluorinated resins, high-reliability adhesives, and select intermediates where both the vinyl and hexafluoro functional groups add value. The integration into resins and copolymers drives performance in sectors such as microelectronics, membranes, and optical components, where chemical resistance and stability at elevated temperatures remain critical requirements. Research organizations also employ 4-HFA-ST as a precursor in the design of next-generation materials with enhanced dielectric or barrier properties.
Quality reflects not just in test results, but also in batch reproducibility and the low frequency of out-of-spec incidents. We rely on in-house analytical labs to monitor identity, purity, and key impurity levels at each step. Retained samples from every production run serve as reference for future traceability. Analytical methods, such as NMR, GC, and HPLC, back up all release data.
Our packaging process addresses the unique handling needs of fluorinated intermediates like 4-HFA-ST. Only certified containers meeting chemical compatibility standards are used, minimizing the risk of leaching or contamination. Packaging formats range from small drums for R&D use to bulk containers for plant-scale supply. Onsite warehousing allows us to offer responsive lead times and secure logistics for regular or custom lot sizes across different regions.
Direct collaboration with process engineers and R&D chemists forms part of our commitment to industrial buyers. Our technical team assists with product implementation, analytical troubleshooting, and selection of grades or packaging options that fit integration guidelines. Buyers benefit from direct access to our manufacturing expertise when developing or scaling new processes using 4-HFA-ST.
Manufacturers, distributors, and procurement professionals engage our direct supply chain for predictable availability, performance consistency, and technical documentation rooted in real production experience. Access to a primary source reduces procurement risk, shortens delivery lead-times, and improves regulatory transparency. With on-site production and dedicated logistics, we support long-term procurement strategies and help industrial partners achieve cost-efficiency in specialty chemical sourcing.
Our technical process for producing 2-(4-ethenylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (4-HFA-ST) gives us firsthand understanding of its behavior from synthesis to shipping. Working with this compound routinely, our staff handles its solid and liquid phases, stores it safely, and ensures product consistency through regular analysis in our own laboratories. Unlike resellers, we do not need to speculate about material characteristics; we observe these in every batch we manufacture.
Many customers ask about thermal characteristics before scaling up or modifying formulations. Experiments in our plant have recorded a defined melting range, fitting with expectations for similar fluoro-alcohols containing a styrenic group. The compound transitions cleanly from solid to liquid without significant decomposition at temperatures typical of our standard purification process. Its boiling point sits much higher owing to the combined effects of the perfluoroalkyl group and phenyl structure. We see no unexpected volatility under ambient conditions, and residues after thermal testing confirm thermal stability within the common application range.
Fluorinated alcohols like 4-HFA-ST offer unique solubility characteristics, useful for specialty coatings, advanced polymers, and as synthetic intermediates. From our R&D test logs, 4-HFA-ST dissolves efficiently in polar aprotic solvents such as DMF and DMSO. It displays limited mixing with water, much like other perfluorinated alcohols, while showing higher affinity for halogenated and aromatic solvents. We found that pre-dissolving 4-HFA-ST in acetonitrile or dichloromethane streamlines blending in diverse formulations. Reports from end users using our direct shipments regularly confirm this observation. Such selective solubility gives formulators options for system compatibility, reactive blending, and precise polymer modification.
In chemical production, knowing how a compound behaves during storage, transport, and reaction is essential. Our staff monitors for color, purity, and potential byproduct formation every production cycle. Alcoholic functionality in 4-HFA-ST makes it reactive under acidic, basic, or catalytic conditions, while the presence of the styrenic vinyl group enables further functionalization. The six fluorines attached to the propan-2-ol backbone contribute to enhanced thermal and chemical robustness. We have performed compatibility testing in presence of common cross-linkers or oligomerizing agents and obtain predictable results, supporting both custom synthesis and regular production cycles.
Our standard packaging uses sealed containers to prevent contamination and environmental exposure, especially for sensitive research and production settings. Each batch is assigned a unique identifier for complete traceability. On request, our technical team issues a full certificate of analysis detailing purity, melting point, and moisture content based on current batch data. Years of direct manufacturing have shown that stable storage below 25°C preserves physical integrity and prevents unwanted reactions. As product stewards, we check compatibility of packaging with both solvent-rich and dry environments, protecting quality from our reactor to your facility.
Supporting customers goes beyond specifications. Our team helps chemists and engineers select the right solvent system, proper melting and dosing procedures, and integration strategies with acrylics, copolymers, or high-performance coatings. Our lab team remains available to consult on new application development or recommend storage upgrades. Ongoing investment into analytical instrumentation and material characterization translates directly into better reliability and material transparency for our customers.
From the manufacturing floor to outbound logistics, experience drives every decision we make concerning the supply of 4-HFA-ST. Years of investment in our dedicated production line allow us to support bulk procurement consistently. Our process control, backed by robust quality management, is rooted in a hands-on approach to reliability and repeatability. Clients operating at scale rely on 4-HFA-ST for its role in their critical downstream applications—so consistent batch reproducibility ranks among our top priorities.
We scale production based on actual demand, and our infrastructure supports inventory planning for steady or project-based requirements. Whether receiving routine monthly releases or handling infrequent large-lot shipments, our output adapts. Plant capacity allows for metric ton-scale orders given sufficient notification for scheduling. Over time, we have invested in direct material sourcing, advanced filtration, and dedicated packing areas to avoid contamination, ensuring our customers receive the required volume on time with every order cycle.
Order minimums are shaped by both technical and logistical factors—raw material handling, process batch sizes, and the resources committed to each production run. For 4-HFA-ST, our current minimum order size is set at 5 kilograms. Setting this limit keeps the supply chain efficient for everyone involved, from raw material intake to final shipment. It reduces the chance of unnecessary waste and keeps turnaround times predictable. For larger quantities, pricing structures reflect realistic production costs and the economies of scale we pass on to clients.
We recognize that packaging matters just as much as batch integrity. Each bulk lot follows our established packaging standard, involving high-integrity drums or lined containers to preserve purity during transit and storage. Special packaging requests get reviewed by our logistics and technical staff, who understand the impact of container choice on handling and downstream use.
Direct technical engagement sets us apart. Our commercial and R&D staff work closely with customers, especially those integrating 4-HFA-ST into new lines or scaling up formulations. Lab-scale samples for evaluation and process validation are available subject to the minimum order policy. All bulk shipments include full batch documentation, and our technical team remains available for post-shipment support related to processing or quality queries.
Making 4-HFA-ST available in consistent, bulk quantities took time and continuous feedback from commercial partners. We’ve responded with upgrades to processing equipment, more advanced analytical testing, and flexible production scheduling. By controlling manufacturing directly, any operational issue is resolved before it reaches the customer. Safety, reliability, and responsiveness stay front and center every day.
For organizations planning larger-scale projects or requiring tailored solutions beyond routine packaging, we coordinate with client operations teams in advance. We understand that clear communication and proactive planning minimize downtime and ensure uninterrupted supply. That’s a direct benefit of working factory-direct—reduced uncertainty, transparent policies, and responsive technical partnership from order to delivery.
For companies shipping 4-HFA-ST worldwide, reliable international delivery rests on much more than logistics and freight selection. As the original manufacturer, every stage—right down to the drum or drum liner—gets shaped by technical demands, safety standards, and a blend of local and global regulations.
Our technical team starts by assessing chemical category. For 4-HFA-ST, established hazard characteristics under GHS drive the issuance of key documents and selection of proper packaging. Tight control over moisture, light, and compatibility with the container matter from the point it leaves our factory gates. Our experience handling hundreds of shipments to markets across Asia, Europe, and the Americas informs our choices. Using UN-certified drums or lined fiber containers is not only regulatory best practice for many finished forms, but helps prevent leaks or interaction during transit. Since international authorities often re-inspect, deviations or shortcuts increase the risk of border delays or denied entry.
Package labeling moves beyond colorful stickers or ink. As a chemical producer, we match CAS numbers, signal words, product names, and pictograms directly onto exterior packaging. Our labels conform to the United Nations GHS framework, referencing both hazard and precautionary statements tailored to the lot and specific route. This is not only a formality: incorrect or absent hazard communication has stopped our clients’ shipments at customs before, leading to fines and return shipments. Each label includes basic physical data and our direct manufacturing details, providing immediate traceability all the way down the supply chain.
Documentation plays a central role. Product shipments include a full Safety Data Sheet (SDS) with up-to-date hazard classification and instructions in the required language, prepared by our regulatory staff or outside experts to ensure compliance with Europe’s REACH, US TSCA, or other regional frameworks. For 4-HFA-ST, importation into major economies often triggers additional pre-notification or registration steps. Markets such as the EU may require a REACH registration number, while Korea or Japan may enforce separate chemical inventory confirmations or prior notice filings. Our regulatory team maintains an ongoing list of destination-specific requirements. Early communication with our clients ensures everyone holds the correct documents at the right stage, pre-empting slowdowns at transshipment ports.
Shipments to certain countries call for Certificates of Analysis, Certificates of Origin, and if needed, other permits showing permitted end use or manufacturer’s declaration. We generate these directly from our plant’s ERP system, matching batch numbers, production dates, and test results in a format accepted by port or customs authorities. Delays often trace back to mismatched paperwork originating from copy-paste errors by third-parties or miscommunication between handlers—not an issue in our process, where the certificate and the batch move together from day one.
As a global producer, we have witnessed rapid shifts in regulatory focus, including emerging rules on environmental impact and classification. Instead of reacting to these only after shipment, our team consults each quarter with regulators, transport partners, and direct customers to review and adapt shipment protocols, update documentation, and issue revised labeling when needed for new routes. A manufacturer’s flexibility in responding to regulatory changes—backed by direct experience moving the actual product across borders—proves essential to reliable supply and satisfied clients.
For product inquiries, sample requests, quotations or after-sales support, please feel free to contact me directly via sales9@bouling-chem.com, +8615651039172 or WhatsApp: +8615651039172
