| Names | |
|---|---|
| Preferred IUPAC name | 1-(2,6-dichloro-3-fluorophenyl)ethan-1-one |
| Other names | 2,6-Dichloro-3-fluorophenyl methyl ketone 1-(2,6-dichloro-3-fluorophenyl)ethan-1-one |
| Pronunciation | /ˈtuː sɪks daɪˈklɔːrəʊ θriː ˈflʊəroʊ æsɪˈtɒfɪnoʊn/ |
| Identifiers | |
| CAS Number | 86393-34-2 |
| Beilstein Reference | 829873 |
| ChEBI | CHEBI:91116 |
| ChEMBL | CHEMBL511506 |
| ChemSpider | 24279940 |
| DrugBank | DB08306 |
| ECHA InfoCard | 03ab26ce-b5e8-4ee3-95a2-48c782efb563 |
| EC Number | 410-180-9 |
| Gmelin Reference | Gmelin 81450 |
| KEGG | C18716 |
| MeSH | D000073678 |
| PubChem CID | 15118710 |
| RTECS number | AM8575000 |
| UNII | 6GCQ7S27PS |
| UN number | UN3439 |
| Properties | |
| Chemical formula | C8H5Cl2FO |
| Molar mass | 206.03 g/mol |
| Appearance | White to Off-White Solid |
| Odor | pungent |
| Density | 1.48 g/cm³ |
| Solubility in water | Insoluble |
| log P | 1.94 |
| Vapor pressure | 0.02 mmHg (25°C) |
| Acidity (pKa) | 15.58 |
| Magnetic susceptibility (χ) | -61.6×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.5670 |
| Dipole moment | 3.11 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 353.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -467.1 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -7726.8 kJ/mol |
| Pharmacology | |
| ATC code | Not assigned |
| Hazards | |
| Main hazards | Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation. |
| GHS labelling | GHS05, GHS07 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H315, H319, H335 |
| Precautionary statements | P261, P264, P271, P280, P301+P312, P305+P351+P338, P337+P313, P405, P501 |
| NFPA 704 (fire diamond) | 2,3,0," |
| Flash point | 110°C |
| Lethal dose or concentration | LD50 (oral, rat): 2150 mg/kg |
| LD50 (median dose) | LD50 (median dose): Oral Rat 1740 mg/kg |
| PEL (Permissible) | Not established |
| REL (Recommended) | 10 mg/m³ |
| IDLH (Immediate danger) | Not established |
| Property | Description |
|---|---|
| Product Name & IUPAC Name |
2,6-Dichloro-3-Fluoro Acetophenone IUPAC: 1-(2,6-Dichloro-3-fluorophenyl)ethan-1-one |
| Chemical Formula | C8H5Cl2FO |
| Synonyms & Trade Names |
2',6'-Dichloro-3'-fluoroacetophenone 2,6-Dichloro-3-fluorophenyl methyl ketone 3-Fluoro-2,6-dichloroacetophenone Systematic synonyms commonly circulate in R&D, but trade names depend on the application sector. |
| HS Code & Customs Classification | HS Code allocation often follows Chapter 29 for organic chemicals: typically classified under 2914.x for ketones and quinones. Rulings for customs depend on the specific national tariff system. Industrial import flows usually reference HS 2914.39 for substituted acetophenones, subject to confirmation per region. |
Producing 2,6-Dichloro-3-Fluoro Acetophenone draws focus to handling precision throughout synthesis and purification. Starting with raw materials, source quality of dichloroacetophenone and fluorination agents leads to the selection of process route. Each supplier batch typically undergoes identity confirmation and trace impurity screen, targeting halogenated by-products and residual solvents that shift depending on upstream chemistry and reactor material.
Process route selection pivots on both reaction selectivity and cost structure. Direct fluorination methods offer greater throughput for ton-scale output, though side-chain halogen exchange and unwanted nucleophilic substitutions raise in-process impurity burdens. In high-consequence grades, post-reaction purification remains pivotal. Chromatographic refinement or controlled distillation applies when customer specs tighten for electronics or pharma intermediates. For industrial or bulk use, batch washing and phase separation may suffice if downstream formulation absorbs trace non-volatiles.
Critical quality control hinges on batch consistency: internal criteria track color, clarity, GC/HPLC purity, and specific halogen profiles. Final release relies on consistent mass spectral ID and absence of process-specific residuals above internal alert levels. If stricter customer specs arise, tailored analytics deepen, and lot numbers link to retained samples for traceability.
Handling and storage reflect the material’s role as a halogenated acetophenone: containers must resist halide-induced corrosion, and temperature management curbs volatilization risks in supply chain hand-off. Downstream customers indicate that solution stability and formulation compatibility depend on control of impurity classes (such as residual aromatic halides and acid by-products), hence, final product fitness draws on detailed discussion with end-users and, if required, collaborative adaptation of the QC release profile or packaging format.
Product characteristics, process controls, and application fit always reflect a conversation between manufacturing practice, upstream material realities, and the evolving expectations of specialty chemical users.
2,6-Dichloro-3-Fluoro Acetophenone generally appears as a solid at room temperature for most process grades. Color can vary from pale yellow to off-white depending on purity and the presence of trace reaction byproducts. Odor is typically mild and may carry a faint halogenated aromatic note if impurities remain, so odor profile is tightly linked to purification efficiency. Key physical properties such as melting point and boiling point shift with impurity levels and the presence of trace hydrolysis products. For downstream processing and formulation, both bulk density and crystallinity impact handling; these are managed by process crystallization parameters. Industrial operators watch for caking or clumping as indicators of handling or storage issues.
This compound offers solid shelf stability under low-moisture conditions, as hydrolysis and photolytic reactivity chiefly determine shelf life. Substitution on the aromatic ring lends the molecule relative resistance to slow degradation, but storage outside controlled humidity can lead to the formation of phenolic and acid byproducts. Reactivity with strong nucleophiles, bases or reducing agents can induce unwanted impurities and should be avoided during downstream operations. Moisture management and inert gas blanketing drive product preservation in large-scale storage.
Solubility depends strongly on grade and solvent choice: typical batches demonstrate moderate solubility in polar aprotic organics and chlorinated solvents. Hydrophilic impurity carryover from upstream synthesis reduces organic phase solubility and can complicate solution preparations. In our production experience, solubility profiles are confirmed by test dissolutions during QC batch release. Careful drying prior to filling limits solubility drift post-packaging.
Detailed technical specifications differ by intended downstream application and customer region. Standard QC release covers content by HPLC or GC, water by KF, single-point colorimetric test, and key impurity quantitation. Pharmaceutical or electronic grades call for expanded profiles and tighter margins. Bulk technical grade standards are set according to aggregate batch consistency and impurity trends. Impurity maxima and analytical acceptance limits are grade-driven.
Primary impurities originate from incomplete halogenation or Friedel-Crafts acylation side products. Most critical impurity classes include polychloroacetophenones, mono-substituted fluoro species, and hydrolytic fragments. Where required, heavy metal and residual solvent screening expands the impurity profile. Batch impurity maxima are dictated by the tightest customer end use (e.g., API vs. industrial application).
GC-FID and HPLC-UV serve as core quantitation platforms; endpoint titration and colorimetric analysis support batch trends and incoming raw screening. Reference standards and methodology calibration follow internal QC systems aligned with domestic or export compliance requirements. Minor test method modifications respond to impurity profiles observed in process analytics.
High-purity 2,6-dichloroacetophenone and fluorinating agents act as primary feedstocks. Selection of these precursors shapes both the impurity portfolio and batch yield. Supplier reliability and in-house incoming material screening limit batch-to-batch impurity fluctuations and unplanned reprocessing. Chlorinated aromatics from ISO-certified sources support both quality and supply chain traceability.
Direct halogen exchange or electrophilic aromatic substitution routes are viable, with selection based on waste minimization, regulatory requirements, and impurity control. Manufacturing sites choose between batch and semi-continuous protocols depending on plant scale, effluent handling capabilities, and regional wastewater regulations. Fluorination pathways can elevate corrosiveness; process risk assessments weigh containment, corrosion, and byproduct venting.
Crude product composition drives purification strategy—typically sequential extraction, distillation, and recrystallization. Impurity management focuses on removing unreacted precursors and polychlorinated side-products. Real-time analytics monitor end-point and fraction collection steps, with process deviations prompting rapid on-line adjustment. In-house engineered controls reduce manual batch interventions, improving both yield and worker safety.
Release testing includes multi-point chemical purity, impurity quantitation, residual solvent checks, and moisture content analysis. Individual batch parameters reflect both process batch history and final use-case requirements; QA and customer technical protocols can add to the panel. Consistency and traceability take precedence in QA documentation to support downstream traceability in regulated uses.
Downstream functionalization favors nucleophilic substitution, reduction, and cross-coupling. Stability of the aromatic core in standard conditions opens possibilities for diversification to substituted derivatives. Acyl and halogen substituents remain sensitive to strong nucleophiles or prolonged base exposure, which sets the operational window for reaction optimization.
Reaction conditions depend on the derivative being targeted. Halogen-exchange and substitution require phase management and can demand either polar aprotic or halogenated solvents. Catalyst and base choices must balance activation with minimization of undesired rearrangement or decompositional side-products. Batch experience shows product grade can shift with solvent aging and trace moisture; process analytics monitor for these vectors.
Process suitability for making custom analogs, such as further halogenated, alkylated, or reduced aromatics, depends on batch purity, trace metal content, and initial impurity carryover. Residual catalyst and solvent must be monitored closely where high performance or regulated end-use is targeted.
Long-term storage enforces low moisture and ambient darkness. Product is filled under inert gas or dry-air blanketing when grade or customer specification dictates. Elevated temperature or direct sunlight elevates risk of discoloration and increases off-odor formation as phenolic breakdown products appear. Warehousing standards call for dry, temperature-stable storage, and secondary containment for bulk volumes.
Suitable packaging includes high-integrity HDPE, fluoropolymer, or lined steel drums. Compatibility checks account for permeation, extractables, and corrosion. Bulk transfer favors closed systems to minimize ingress of atmospheric moisture or process dust.
Shelf life varies with grade, impurity profile, and storage stringency. Early batch degradation manifests as increased color, altered odor, or impurity drift detected by regular QC stability monitoring. Out-of-spec product will typically be identified before end-user receipt under manufacturer-led batch rotation and reserve sample programs.
This material has been evaluated for GHS chemical hazard communication where legally required. Final classification, pictograms, and precautionary phrases reflect both intrinsic toxicity and the potential for skin, eye, and respiratory irritation, as documented by toxicological screening data and regulatory inputs. Actual labeling and SDS language depend on the regional regulatory environment and intended application sector.
Toxicity profile is influenced by batch purity, residual halogenation agents, and impurity spectrum. Industrial production departments adhere to stringent PPE, ventilation, and containment controls at all stages to minimize inhalation and dermal exposure, especially during open handling, blending, or transfers. Spill containment and first response strategy are facility-defined, supported by real-time air monitoring at the filling and packaging lines in high-throughput operations.
Quantitative toxicity and occupational exposure limits correlate directly with batch-specific impurity spectra, downstream application and product grade. Internal risk assessments and operator training are adjusted batchwise as new toxicological or regulatory data becomes available. Handling and disposal procedures evolve as analytical data clarifies long-term effects and byproduct risks. Product knowledge and hazard communication training are maintained for all operational and QC staff involved in the product’s lifecycle.
Production output for 2,6-Dichloro-3-Fluoro Acetophenone fluctuates by season and grade requirements. Synthesis scale depends on both internal capacity allocation and third-party supplier contract stability for halogenated intermediates. Facility batch size and uptime are directly impacted by substrate availability and reactor changeover times between grades. If downstream users require higher purity or tailor-made specifications, actual availability narrows due to more aggressive purification requirements and increased analytical testing commitment per lot. Tight capacity years result primarily from bottlenecks in raw material chlorination purity or fluoro-substituent availability, not always from plantside mechanical limits.
Standard lead times for regular catalog grades usually fall within a few weeks from order confirmation, assuming precursor inventory aligns with forecasted need. Custom or higher-purity grades may encounter shifts, often requiring several additional weeks to manage special purification or sequential analytical release. MOQ terms fluctuate with grade, as higher assay thresholds cause reduced batch yields, pushing up practical minimum runs. Scheduled supply is prioritized for contract clients, with short-notice availability for spot buyers being less certain during periods of raw material disruption.
Industrial packaging for 2,6-Dichloro-3-Fluoro Acetophenone typically aligns with supply chain constraints and chemical compatibility. Standard bulk shipments utilize mono-layer HDPE drums or lined steel cans. Custom packaging, such as nitrogen-flushed or smaller pack sizes, addresses customer process needs, either for pilot reactivity screening or for high-containment workflows where exposure control is required. Grade-specific handling may call for tamper-evidence or inert gas overlays in case of oncology or electronics-grade supply; options are determined based on customer and regional transport safety norms.
FOB, CIF, and DAP structures are available depending on customer contract history and credit status. Most bulk export shipments pass through coastal transshipment routes, subject to regional hazardous material documentation standards. Payment cycles are determined by long-term customer reliability, with new accounts normally on prepayment until standard credit history is established. Insurance and carriage terms reflect regulatory status of the substance under IMDG and IATA.
The cost structure for 2,6-Dichloro-3-Fluoro Acetophenone traces steeply to sourcing reliability of halogenated aromatic precursors and fluorinating agents. Typical grades require feedstocks derived from multi-step halogenation and selective fluorination, with price spikes occurring during supply chain events such as force majeure at fluorine gas producers or when upstream monochlorobenzene pricing shifts on commodity cycles. Waste disposal surcharges and energy tariffs, especially from regulated halogen effluent handling, also direct input costs on a month-to-month basis.
Price gaps across grades reflect not only starting purity but also incremental labor and testing, with GMP or electronics applications demanding additional release checks (such as trace metal or particle content). Custom certification, third-party audit traceability, or specialized packaging (e.g., antistatic lining, moisture-sensitive drums) result in layered pricing structures, as each step in documentation and handling protocol absorbs resources not applicable to standard-tech grades.
Final unit cost tracks with the number and type of batch release parameters, not simply nominal assay. For pharmaceutical or electronics applications, lot release includes stability assessment, impurity profiling, and occasional customer-referenced recombinant batch control, each driving incremental costs.
Demand for 2,6-Dichloro-3-Fluoro Acetophenone aligns with agrochemical and pharmaceutical program launches, particularly in North American and European regulatory jurisdictions. Demand surges often follow specific campaign launches in crop science or patent expiry wavefronts. Typical supply-side constraints arise in years where major Asian suppliers face environmental audits, causing production quota suspensions or new plant commissioning delays.
Production in China accounts for most commodity-grade output, often feeding regional formulators and toll blenders. Japan and the US command high-assay, traceable lots for electronics and pharma markets, leading to higher per-kilo valuations backed by stricter vendor prequalification. EU buyers prioritize supply chain transparency and packaging stewardship, with additional due diligence actions for SVHC and REACH compliance. India contributes both to upstream intermediate production and as an integrated downstream consumer, smoothing out some year-on-year volatility with local capacity ramp-ups.
Barring major geopolitical or regulatory shifts, 2,6-Dichloro-3-Fluoro Acetophenone is expected to follow input cost inflation and environmental compliance cost increases. Extended global environmental audits and new PFAS and halogen-specific regulations could lift raw material and waste-handling surcharges. Price divergence between bulk industrial and high-purity grades may widen further if new regulatory quality assurance schemes take effect in major pharma and electronics consuming geographies.
Analysis draws on internal customer order patterns, major consortia demand forecasts, customs and trade data, and conversations with raw material suppliers. Process-side observations rely on annual production cycle audits, batch yield analysis, and third-party audit outcomes.
Major East Asian production hubs have reported regulatory inspections focusing on halogenated waste minimization. In some cases, government-mandated shutdowns or output reductions curbed supply, particularly for high-throughput grades. EU clients requesting next-level documentation for product stewardship continue to influence batch documentation protocols that, in turn, shape batch size and composition.
REACH updates prompt changes in documentation for substance traceability, especially for products destined for the European market. Several regions now require batch-specific impurity profiles and extended shelf-life proof, which drives additional analytical controls upstream. North America’s movement toward PFAS restriction and disclosure notices affected some precursor selection decisions, increasing scrutiny on feedstock traceability and supplier transparency.
To stabilize output, raw material procurement shifted toward longer-term contracts with curated supplier pools that meet dual audit requirements. Process modification projects target both yield improvement and reduced halogenated waste streams, aiming to satisfy upcoming waste minimization targets. Where required, new batch release documentation protocols emphasize traceability, with QA and compliance acting in parallel rather than sequential release points.
Production of specialized agrochemical intermediates, pharmaceutical building blocks, and select electronic industry chemicals draws on 2,6-Dichloro-3-Fluoro Acetophenone for its halogenated aromatic structure. In the agrochemical sector, this molecule serves primarily as a synthetic intermediate in fine-tuning target-specific compounds. Pharmaceutical manufacturers utilize higher-purity grades for building proprietary molecules, most often where trace halogen content or tightly controlled related substances present key quality control checkpoints. Semiconductor-related applications demand material with very low metal content and minimal organic impurities, as contamination can directly interfere with device performance. These three segments represent the main technical bases driving production and grade development.
| Application Segment | Preferred Grade | Key Quality Drivers |
|---|---|---|
| Agrochemicals | Technical Grade | Total purity, bulk organic impurities profile, batch-to-batch reproducibility |
| Pharmaceuticals | Pharma/Custom Grade | Purity (HPLC), related substances, residual solvents, elemental impurities as per ICH Q3D |
| Electronic & Specialty | Electronic Grade | Total metals (ICP), halide content, particle sizing (if solid), ultra-low moisture |
Technical grade targets overall purity and manageable impurity content for synthetic use across large-scale agricultural production. High-end pharmaceutical or electronic applications prioritize the tightest impurity control, with specifications established in consultation with end users. While bulk handling and storage conditions typically follow standard protocols in technical applications, tighter atmospheric and contamination controls become necessary in GMP or cleanroom processing.
Assess the end use and quality risk. Agrochemical syntheses tolerate broader impurity ranges if conversion is not impacted. For pharmaceuticals, the focus shifts to both impurity profiles and compliance expectations tied to global regulatory filings. Electronic applications require full disclosure and minimization of trace elements, including transition metals, which can stem from reactors or process lines.
Determine which national or international compliance bodies govern the material in the intended end use. Regulatory orientation influences whether a customer-supplied open part specification or internal “fit for purpose” spec serves as the acceptance standard. Management of compliance documentation is carried out at the manufacturer’s QA level, especially for pharma or critical applications, where quality agreements may drive specification setting and batch release.
Match required minimum purity with intended reaction or formulation. Our production team differentiates between main component assay, related substance control, and elemental profile per grade. Methods such as HPLC/GC for organic contaminants, ICP-MS/ICP-OES for elemental traces, and KF for water are brought online or enhanced as needed. The depth of impurity profiling increases with regulatory stringency and application risk.
Grade definition closely follows project scale and cost control. Technical or bulk users often prioritize cost efficiency and robust upstream supply; custom or pharma grade lots may be smaller, requiring targeted purification runs or multi-stage refinement, which increases analytical workload and cost per kg. Batch sizes, inventory planning, and grade pricing are discussed during technical reviews or supply chain planning.
Customers are encouraged to work with our technical service team to acquire representative samples. Laboratory or pilot-scale validation enables direct data on product compatibility and downstream yield. Internal QC controls document every test performed per sample, ensuring traceability and reference for troubleshooting.
Across all grades, raw material selection focuses on traceability and known impurity profiles—chlorinated and fluorinated benzene derivatives introduce predictable impurity risks, such as over-chlorinated species or unidentified byproducts from minor side reactions. The chosen process route, solvent system, and isolation method control the quantity and concentration of co-produced impurities. Continuous process control monitors parameters such as reaction temperature and reagent feed rate, supported by periodic in-process checks for color, clarity, and phase purity.
Purification strategy, especially for high-purity or electronic grades, incorporates additional solvent extractions, recrystallization, and—if required—sublimation or high-vacuum distillation, supported by stepwise impurity monitoring. Production batches integrate batch consistency management through real-time trending and historical lot review, releasing only upon meeting all agreed customer or regulatory criteria.
In producing 2,6-Dichloro-3-Fluoro Acetophenone, all core processing steps fall under an integrated quality management system audited for compliance with relevant ISO standards. These certifications demonstrate our long-term commitment to manufacturing reliability and continuous monitoring of production variation. Internal audits cover risk management, batch traceability, change control, and periodic supplier qualification to control upstream variables that influence intermediate and final product quality.
Our release protocols center on batch-level certification. Typical values in certificates of analysis include assay, major and minor impurity profiles, moisture content, and analytical identification results. Required test items and target values vary by customer application and market. Pharmaceutical, fine chemical, and advanced electronic applications may trigger additional residual solvent, metal, or trace contaminant checks. Custom testing, as defined during qualification procedures, remains available for customer-directed compliance regimes. Regulatory documentation is provided as requested for compliant import, export, or regulated downstream processing.
Batch documentation consists of production records, technical analysis, stability investigation results, and logistics compliance. Analytical results come backed with chromatograms and instrument parameters on request. Product grade, synthesis route, or customer end-use standards drive adjustments to test scope and frequency. Purity, specific contaminant thresholds, and storage condition recommendations are reflected in technical documentation, which is updated to match process refinements and regulatory guidance.
Our manufacturing site operates with dedicated capacity for 2,6-Dichloro-3-Fluoro Acetophenone by leveraging multi-purpose reactors and validated production scheduling. Demand forecasting and buffer strategies support consistent output, even during supply chain disruptions or order surges. Production planning teams work with customers to secure advance volumes and flexible contract models, matching procurement cycles to consumption peaks and new project launches.
Upstream raw material security, verified second-source vendors, and dual-route synthesis options are maintained to minimize potential disruption. Each step in the process sits under capacity review, including purification, isolation, and secondary packaging. For long-term projects or new application launches, scale-up capability is justified by historical batch performance data, run-to-run impurity monitoring, and tracked yield optimization.
Sample requests engage both our technical sales and analytical teams to ensure representative material is provided. Typical sample shipment includes supporting certificates, analytical results, and relevant MSDS documents. For critical validation or regulatory filing, additional data can be supplied after consultation with our QA and analytical departments. Sample grades reflect the proposed commercial supply, including batch process documentation and analytical release specs.
Flexible arrangements account for lead time, custom packaging, bulk or campaign production, and multi-site delivery. Projects requiring JIT supply, phased shipments, or target impurity profiles are coordinated through direct communication between customer technical teams and our production planners. Risk sharing models, consignment stock, or volume guarantees may be proposed based on project risk analysis, historical supply stability, and investment in dedicated resources.
Development activity for 2,6-Dichloro-3-Fluoro Acetophenone centers on reaction selectivity, impurity control, and expanding the range of suitable derivatives. In-house chemists continuously evaluate halogenation and acylation conditions to maintain batch-to-batch consistency. Upstream, there is significant interest in precursor selection to minimize regulated impurities. Downstream, customers in agrichemical and pharmaceutical intermediates emphasize tailored purity for specific formulations, which drives investment in route screening and analytical technology.
Intermediates like 2,6-Dichloro-3-Fluoro Acetophenone often advance into crop protection, specialty polymers, and next-generation active ingredients. R&D labs target applications where halogen-substituted acetophenones provide molecular scaffolds for selective, high-value synthons. Focus areas include fluorinated benzoyl compounds for proprietary APIs and platform molecules for advanced materials, with demand scenarios shaped by both regulatory shifts and the migration of manufacturing from Europe to Asia for cost and scale advantages.
Controlling trace halogenated byproducts remains a persistent technical challenge. High-precision control of reaction environment, choice of catalyst, and handling of corrosive feeds requires investment in corrosion-resistant reactors and closed transfer systems. Periodic advances come from integrating in-line analytics, which reduces batch failures and supports quick release. When stringent customer limits dictate, multi-stage distillation and carbon treatment are deployed. Batch reproducibility gets priority in multi-ton scale production, supported by digital process monitoring and trend analysis to catch deviations before downstream release.
As active ingredient portfolios diversify and regulatory landscapes evolve, multi-functional intermediates with halogen and fluorine groups see stable demand in Eastern and Western production hubs. Sector volatility can arise from shifts in agrochemical actives registration, alongside R&D pipelines in generics and specialty polymers adapting to new environmental standards. In the next 3–5 years, manufacturers anticipate a gradual increase in inquiries for custom grades and tighter impurity profiles, with customers pushing for more analytical support to align with global REACH and TSCA frameworks.
Incremental gains in production efficiency come from continuous flow processing and digitalized batch control. Physical separation technology advances, such as high-vacuum distillation and precision crystallization, adapt to the purity demands of active pharmaceutical ingredient (API) projects and high-purity electronic chemicals. Investment in upstream process intensification gives access to consistent quality, while improved process data integration aids in proactive customer technical support and audit transparency.
Raw material sourcing increasingly favors lower-toxicity substitutes and renewable feed streams where risk and availability parameters allow. Chlorinated and fluorinated intermediates face extra scrutiny under evolving environmental regulation, so process design shifts towards reducing mother liquor waste, solvent recycling, and minimizing energy load in reprocessing. New technologies under evaluation include catalytic halogen exchange and solventless processes, intended to lower both emissions and operator exposure throughout the value chain.
Technical support is led by chemists who take direct responsibility for application-specific advice—whether adapting grade selection to formulation requirements or troubleshooting process compatibility for new synthesis routes. Customer queries range from solubility profiles to impurity carryover risk, with recommendations always benchmarked against actual archived batch data instead of generic statements. Consultation scope extends to regulatory documentation and specialized certificates on request.
Downstream processing teams often require assistance on reaction setup, dilution protocols, or impurity deconvolution within customer-specific matrices. Troubleshooting blends practical experience gained from plant operations with in-field case data logged from previous customer campaigns. When process modifications or formulation changes arise, technical staff are available to provide adaptation guidance, including stability testing protocols, alternative solvent strategies, or packaging recommendations tied to shipment integrity.
Quality assurance does not end at delivery. Each batch receives full technical release based on internally audited criteria and customer contract requirements. Support teams respond rapidly to customer feedback on appearance, performance, or analytical variance, drawing on production logbooks and retained sample archives to expedite resolution. Complaint handling triggers a root cause analysis cycle, leveraging process records and trend monitoring to prevent recurrence. Ongoing product stewardship includes regular review of market-led impurity benchmarks and shipping safety protocols. Commitment includes traceability from raw input to shipment, supported by transparent documentation for internal and third-party audits.
We manufacture 2,6-Dichloro-3-Fluoro Acetophenone at our dedicated facility, controlling every stage from raw material selection to final purification. Our technical team operates well-defined procedures developed through years of work with specialty aromatic ketones. By utilizing closed-system reactors and continuous quality review at critical steps, we consistently deliver material that meets stringent specification requirements. Batch records and traceability allow us to tighten control and minimize process variability for every shipment.
Our primary clients utilize 2,6-Dichloro-3-Fluoro Acetophenone in advanced chemical synthesis. The compound acts as a versatile intermediate for the development of active ingredients used in pharmaceuticals and agrochemical formulations. Multistep syntheses within the fine chemical sector rely on the reactivity profile and substitution pattern this molecule provides. Formulators working in these sectors value predictable performance, high assay, and consistent physical properties that integrate smoothly into pilot and production-scale processes.
Each lot we ship undergoes a release protocol with defined analytical checkpoints. GC, NMR, and HPLC profiling confirm composition, and reference spectra for every lot provide additional verification. We reject any batch that falls outside customer-agreed parameters for purity, moisture, or critical impurities. Our plant chemists routinely calibrate instruments and update in-process monitoring strategies in response to regulatory changes or customer feedback, reducing the chance of deviation before a product leaves our facility.
We package 2,6-Dichloro-3-Fluoro Acetophenone at source, using lined drum and hazard-compliant container options to suit downstream operations. In-house packaging lines reduce contamination risks and maintain product integrity during transport and warehousing. Standard configurations meet the requirements for both bulk tanker and controlled small-pack consignments. For export markets, experienced staff manage all logistics documentation and customs interface, avoiding unwanted delays and bottlenecks.
Our product support goes beyond delivery. Technical teams routinely assist formulation chemists and process engineers on questions linked to batch reproducibility, reactivity, and compatibility in downstream synthesis. Case studies from past projects guide users facing process upsets or seeking yield improvement. This direct access to technical personnel ensures challenging requirements or unexpected process issues do not delay commercial project timelines.
Manufacturers and procurement teams source from us to gain predictable lead times and technical backed solutions. Volume flexibility, supply chain transparency, and full specification documentation form the cornerstone of our customer partnerships. By integrating production and supply, we deliver added value through traceable quality, minimized risk, and direct feedback loops for ongoing process optimization.
Manufacturing 2,6-Dichloro-3-Fluoro Acetophenone demands a solid grasp of its molecular structure and properties. This compound brings together three key substituents on an acetophenone backbone: two chlorine atoms, one fluorine atom, and a carbonyl-linked methyl group. Direct experience with these types of substituted aromatic ketones tells us: every atom’s position matters – not just for performance in downstream synthesis, but also for safety and handling during production.
On paper, the chemical formula reads C8H5Cl2FO. The core structure consists of a benzene ring. At the 2 and 6 positions you find chlorine atoms, the 3 position holds a fluorine atom, and on the 1 position we attach the acetyl group (COCH3). The result looks like this:
O=C–CH3 linked to a benzene ring, with Cl atoms at positions ortho to the ketone and a F atom between them on the ring. Chemists often call this arrangement “2,6-dichloro-3-fluoro-1-acetophenone.”
Our team synthesizes this molecule by selective halogenation and careful protection strategies to ensure the right substitutions land at the intended positions. Any misstep changes the product’s behavior in subsequent reactions, dyes, or pharmaceuticals. Correct regiochemistry isn’t a luxury—it's critical for consistent, reliable properties batch after batch.
The molecular weight of 2,6-Dichloro-3-Fluoro Acetophenone checks in at 207.03 g/mol. This number stems from precision mass balances in our laboratory during both R&D and full-scale production. Knowing the exact molecular weight is absolutely essential; even minor impurities can skew results in formulation or scale-up, especially as customers downstream apply this compound in specialty syntheses or analytical standards.
Inside our plant, we verify molecular weight during final QC using techniques like mass spectrometry and NMR. These checks ensure that every drum, can, or flask leaving our facility matches the customer’s expectations, not just on paper but in real-world application. Data integrity in these steps isn’t a formality—it’s our commercial guarantee.
From an operational perspective, the exact structure guides choice of reagents, solvents, temperatures, and even reactor materials. Fluorinated aromatics react differently than their non-fluorinated counterparts. Chlorine substitutions introduce unique considerations for waste management, corrosion resistance, and worker safety. Every aspect—right down to packaging—must fit the chemical’s profile. Our standard packaging accounts for both stability and regulatory compliance, minimizing risk in storage and shipment.
2,6-Dichloro-3-Fluoro Acetophenone often serves as an intermediate in pharmaceutical, agrochemical, and fine chemical production. Customers require traceability back to each batch’s synthetic route and a full certificate of analysis with structure-confirming spectra. Our technical team remains available to help interpret any structural or analytical questions, based on hands-on process knowledge not available from dealers or traders.
Direct from our manufacturing floor, we offer more than raw material—we deliver structural reliability, full transparency, and fast response to technical needs, anchored in years of industrial chemical production.
As the direct manufacturer, we receive frequent inquiries about the minimum order quantity (MOQ) for 2,6-Dichloro-3-Fluoro Acetophenone. Decisions around MOQ tie closely to several practical factors in the plant—raw material sourcing, scale of batch production, and downstream handling. Our MOQ for this product typically starts at 1 kilogram. We set this benchmark because processes such as solvent recovery, reaction efficiency, and waste minimization do not scale down well below this level. Running smaller batches leads to unnecessary risk of diminished quality and higher costs per unit. Keeping the MOQ at this level allows us to offer a competitive price for research and pilot-scale applications while maintaining workflow efficiency.
Production lead time reflects both the complexity of synthesis and the realities of plant scheduling. For 2,6-Dichloro-3-Fluoro Acetophenone, a typical lead time sits within 2 to 4 weeks for standard orders, starting from date of order confirmation. This estimate covers the entire cycle: raw material allocation, synthesis, purification, analysis, and packing. Complex orders that fall outside standard kilogram packaging—such as custom blends, larger-volume drums, or requests for alternative solvents—can extend lead time accordingly.
Several factors influence this timeline, especially upstream supply consistency. Critical starting materials must meet stringent in-house specifications and pass incoming checks. Deviations—such as moisture, particle size, or minor impurities—can delay the entire batch as our technical team completes thorough re-qualification. All this, while sounding routine, keeps every kilogram conforming to customer demand and regulatory expectation.
Urgent requirements do arise, particularly within pharmaceutical R&D or fast-moving agricultural trials. We keep a certain amount of finished inventory for such cases. Our operations team can release these stocks, routed through proper QA, for shipment within several days. Predictability drops when market volatility surges, such as sudden disruptions in the upstream halogen markets or logistics gridlocks. We've seen these scenarios force temporary extension of lead times, though our procurement and planning departments work to insulate ongoing projects from such shocks.
Many clients need not just the product, but also accompanying documentation—CoA, MSDS, REACH status, or country-specific registrations. Our regulatory affairs group maintains up-to-date dossiers, which streamlines the process for export clearances and project qualification. If a new registration or additional testing becomes necessary, timelines can stretch slightly to account for the required analysis.
From decades of experience, we recognize that timely supply beats theoretical minimums on paper. Running the plant with disciplined procedures and realistic batch size models keeps MOQs rational and lead times achievable. Our technical managers regularly survey customers, feeding comments back into the production planning loop. This feedback has led to better stock management and process improvements across campaigns. We stay in close communication with active clients to align production runs with project go-lives—not just shipping what sits on the shelf, but anticipating future needs.
Direct dialogue with the factory ensures accuracy and dependability throughout every transaction. Our entire production and commercial infrastructure is built to support clear answers to these key questions on MOQ and lead time, keeping projects supplied and on schedule.
Transporting chemical products across borders is never a routine process, especially when handling a complex aromatic compound like 2,6-Dichloro-3-Fluoro Acetophenone. Our team oversees production from raw material selection to packaging, so the requirements for shipment don’t catch us by surprise. Regulatory expectations—you either meet them, or you don’t ship.
A compound with halogen atoms—chlorine and fluorine—on an acetophenone backbone is bound to attract regulatory attention. It’s classified as a fine chemical intermediate, but authorities usually check if it connects to pharmaceutical, agrochemical, or other sensitive sectors. The Safety Data Sheet and technical dossier from us always reflect the product’s hazard classification according to the latest GHS guidelines. Most imports or exports of this compound fall under hazardous goods regulations. For each shipment, our logistics staff prepares the relevant UN numbers and proper shipping names to ensure the cargo moves through customs without delay.
Not every customer realizes the paperwork extends well beyond a packing list and commercial invoice. For our acetophenone derivative, documented classification as a hazardous chemical is standard. We furnish a complete set of transport documents—often including a Material Safety Data Sheet with shipping section, Dangerous Goods Declaration, and Classification Confirmation—in accordance with IMDG (sea), IATA (air), and ADR (road) codes. Only after these are in place will we move drums from our plant to the container yard.
Authorities may require an export license for certain countries, particularly if end-use looks sensitive or national regulations place halogenated aromatics on a control list. Our export compliance team tracks updates and manages registration records in several destination jurisdictions. We submit technical dossiers or pre-shipment notifications where regulations call for them—there’s no room for guesswork or shortcuts in today’s compliance environment. In our experience, officials at destination ports sometimes request verifiable proof of origin, so we provide stamped Certificates of Analysis and batch traceability from our site.
Depending on state or international frameworks, importers can also face prerequisite licenses or pre-clearances specific to this class of chemicals. More than once, a batch waited at port because a buyer’s environmental permit lagged behind. To keep customers and goods moving, we stay proactive: pre-shipment audits, up-to-date SDS, container labeling, and packaging conform to global transport rules—our factory codes and serials verify every batch.
Hazard labeling walks hand-in-hand with proper packaging, so we supply UN-certified drums or IBCs. Our batch records and transport decks include emergency response info per international transport demands. No manufacturer wants authorities to suspend a shipment for missing paperwork, so our operations, regulatory, and export teams coordinate on every consignment. Each package leaves our site with the documentation required for customs and border entries—customs only sees officially documented material, never informal shipments.
Global chemicals trade brings challenges, but by taking full control—from synthesis lines to container seals—we reduce risk and guarantee traceability. Our business does not depend on shortcuts; compliance supports our reputation and customer trust. Documentation is more than bureaucracy in this field—it’s the line between seamless delivery and expensive storage delays.
For product inquiries, sample requests, quotations or after-sales support, please feel free to contact me directly via sales9@bouling-chem.com, +8615651039172 or WhatsApp: +8615651039172
